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similar carbon alpha RMSDs for amino acids in the models of AT1, AT2, and MAS in a lipid membrane. The seven transmembrane domains are numbered all showing stability of movement relative to the loops. (TIF) Figure S3 AT1 sequence alignments from multiple species. Consensus alignment show amino acids 100 conserved, those conserved as a hydrophobic amino acid as a (A, V, L, I, F, W, M, P), polar ac
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nt in both Mtap+/+ and Mtap2/2 animals.Loss of Mtap Protein Expression in Lymphoma CellsWe next examined Mtap expression in lymphoma-infiltrated tissue from 26 MtaplacZ/+ and 17 Mtap+/+ animals by Western blot analysis (Fig. 3A). We found that 13/26 (50 ) of the tumors from MtaplacZ/+ mice showed complete loss of MTAP protein compared to 5/17 (29 ) of the tumors from Mtap+/+ mice, but this differe